, lightheadedness, dizziness, or loss of consciousness from IOH, affects up to 40% of the general population (all ages), while presyncope is probably even more common. Despite this, the condition is relatively understudied and there is minimal information available about the underlying mechanisms or symptom management and treatment. Currently, there are very few options available to patients with IOH and no pharmacological treatments. The most common recommendations have been to stand up slowly or sit up first before standing.

"Almost everyone has probably experienced some lightheadedness at some time after standing up," explained lead investigator Satish R. Raj, MD, MSCI, FHRS, Professor of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. "For some people this is a frequent occurrence and may happen several times a day, which can be very frightening and negatively impact their quality of life. We wanted to explore this further and provide novel and effective symptom management techniques with the goal of improving the IOH patient's quality of life."

This study investigated physical maneuvers before or after standing and their efficacy in reducing the drop in blood pressure as well as the symptoms typically seen in IOH patients upon standing. Study participants included 24 young women (mean age 32 ? 8 years) with a high burden history of fainting immediately after standing and more than four episodes of presyncope or syncope per month. The study participants were required to have a significant drop in systolic blood pressure of at least 40 mmHg upon standing to fulfill the diagnostic criteria of IOH on the study day. Two participants had inadequate heart rate recordings and were excluded from the analysis.

The 22 study participants completed three sit-to-stand maneuvers including a stand with no intervention (control), and two interventions. Researchers found that both lower body muscle preactivation (thighs) through repeated knee raises prior to standing (PREACT) and lower body muscle tensing (thighs and buttocks) through leg crossing and tensing immediately after standing (TENSE) effectively improve the blood pressure drop. This led to a reduction in symptoms upon standing. They found that the PREACT maneuver accomplished this by increasing cardiac output, while the TENSE maneuver did so by increasing stroke volume.

"Our study provides a novel and cost-free symptom management technique that patients with IOH can use to manage their symptoms," noted first author Nasia A. Sheikh, MSc, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. "Since it is a physical maneuver, it simply requires the lower body limbs, which patients can utilize at any time and from anywhere to combat their symptoms."

"Our study demonstrates the physiology of IOH and assesses the utility of physical maneuvers that can help the IOH patient manage their symptoms. A diagnosis of IOH is identified by patients as the critical first step to empowering them to understand and master their symptoms and thus minimize the disruptions to daily living caused by this common, but not commonly understood, condition," added co-investigator Mary Runte, PhD, University of Lethbridge, Lethbridge, AB, Canada.

In an accompanying editorial, Bert Vandenberk, MD, PhD, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; and Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium; and Carlos A. Morillo, MD, FHRS, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, commented that "PREACT and TENSE provide an elegant and simple effective symptom relief option for patients with IOH." However, they noted, "The study needs to be validated in men, as well as being explored in the elderly where multiple confounders should be addressed. Understanding the role of cardiopulmonary mechanoreceptors should also provide further mechanistic insights into the effects of these simple yet very effective physiologic maneuvers."

And?



--- WinPoint Beta 5 (359.1)
* Origin: 21-st century (1:153/757.1315)

Hi All,

On 2022-02-10 10:33:41, Denis Mosko wrote to you:

@MSGID: 1:153/757.1315 30f7d089
@CHRS: CP866 2
@TZUTC: 0300
, lightheadedness, dizziness, or loss of consciousness from IOH, affects up

[...]

mechanistic insights into the effects of these simple yet very
effective physiologic maneuvers."

And?

--- WinPoint Beta 5 (359.1)
* Origin: 21-st century (1:153/757.1315)

Is someones bluewave config fucked up again? Or is this just spam? :-(

Bye, Wilfred.
--- FMail-lnx64 2.1.0.18-B20170815
* Origin: FMail development HQ (2:280/464)

//Hello Wilfred, //

*10.02.22* *9:15:13* in area *ASIAN_LINK*
*All* Theme *"Re: Syncope, "*.

Hi All,

On 2022-02-10 10:33:41, Denis Mosko wrote to you:

@MSGID: 1:153/757.1315 30f7d089 @CHRS: CP866 2 @TZUTC: 0300 ,
lightheadedness, dizziness, or loss of consciousness from IOH, affects
up

[...]

mechanistic insights into the effects of these simple yet very effective
physiologic maneuvers."

And?

-+- WinPoint Beta 5 (359.1)
* Origin: 21-st century (1:153/757.1315)

Is someones bluewave config fucked up again? Or is this just spam? :-(

Wilfred, sometimes congig fucked up.
--- WinPoint Beta 5 (359.1)
* Origin: "Novy jemchug" for :-D (1:153/757.1315)

On 2/10/2022 3:22 AM, between "Denis Mosko - Wilfred van Velzen":

And?

-+- WinPoint Beta 5 (359.1)
* Origin: 21-st century (1:153/757.1315)

Is someones bluewave config fucked up again? Or is this just spam? :-(

Wilfred, sometimes congig fucked up.

--- WinPoint Beta 5 (359.1)

^^^^^^^^^^^^^

It might be worth upgrading to the most recent WinPoint as well.

+=====================================+
| # # #### |
| # # # # WinPoint |
| # # #### Version 398.2 |
| # # # # |
| # # # Released 2022-02-06 |
+-------------------------------------+
| Complete Point Software for Windows |
+-------------------------------------+
| Most notable changes since V.394 |
| .NEW Text groups now support Unicode|
| .NEW Improved editor quote handling |
| .NEW Improved message list/tree |
| .NEW Improved mailer/tosser reports |
| .NEW Various minor improvements |
| .FIX Enabled Automatic maintenance |
| .FIX English locale was broken |
| .FIX Various bug fixes |
+=====================================+

"Hello All,

"an updated WP version is available at

"http://www.winpoint.org/WP_398_2.zip

"Lots of small improvements since 397 :)

"Will also put it visible on the web site later.

"Regards,
"Tim
"--- WinPoint 398.2
" * Origin: Original WinPoint Origin! (2:240/1120.29)
---
* Origin: nntp://news.fidonet.fi (2:221/6.0)

Re: Re: Syncope,
By: Wilfred van Velzen to All on Thu Feb 10 2022 09:15 am

Hi All,

On 2022-02-10 10:33:41, Denis Mosko wrote to you:

@MSGID: 1:153/757.1315 30f7d089
@CHRS: CP866 2
@TZUTC: 0300
, lightheadedness, dizziness, or loss of consciousness from IOH, affect

up
[...]

mechanistic insights into the effects of these simple yet very effective physiologic maneuvers."

And?

--- WinPoint Beta 5 (359.1)
* Origin: 21-st century (1:153/757.1315)

Is someones bluewave config fucked up again? Or is this just spam? :-(

Bye, Wilfred.

I suspect they ent to hit ABLED but got here by accident.

xxcarol
--- SBBSecho 2.11-Win32
* Origin: SHENK'S EXPRESS, shenks.synchro.net (1:275/100)

Re: ..sometimes congig fucked up
By: August Abolins to Denis Mosko on Mon Feb 14 2022 12:33 am

On 2/10/2022 3:22 AM, between "Denis Mosko - Wilfred van Velzen":

And?

-+- WinPoint Beta 5 (359.1)
* Origin: 21-st century (1:153/757.1315)

Is someones bluewave config fucked up again? Or is this just spam? :

Wilfred, sometimes congig fucked up.

--- WinPoint Beta 5 (359.1)

^^^^^^^^^^^^^

It might be worth upgrading to the most recent WinPoint as well.

+=====================================+
| # # #### |
| # # # # WinPoint |
| # # #### Version 398.2 |
| # # # # |
| # # # Released 2022-02-06 | +-------------------------------------+
| Complete Point Software for Windows | +-------------------------------------+
| Most notable changes since V.394 |
| .NEW Text groups now support Unicode|
| .NEW Improved editor quote handling |
| .NEW Improved message list/tree |
| .NEW Improved mailer/tosser reports |
| .NEW Various minor improvements |
| .FIX Enabled Automatic maintenance |
| .FIX English locale was broken |
| .FIX Various bug fixes | +=====================================+

"Hello All,

"an updated WP version is available at

"http://www.winpoint.org/WP_398_2.zip

"Lots of small improvements since 397 :)

"Will also put it visible on the web site later.

"Regards,
"Tim
"--- WinPoint 398.2
" * Origin: Original WinPoint Origin! (2:240/1120.29)

Grin, someone tell Tim to get that to Vincent Cohen
2:250/1 if it needs hatching in the filebone.

Janis has seemingly come back up but I don't know the status of her filebone yet.

xxcarol
--- SBBSecho 2.11-Win32
* Origin: SHENK'S EXPRESS, shenks.synchro.net (1:275/100)